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Viagra (Sildenafil citrate), which millions of men take for erectile dysfunction (ED), reduces the effects of hormonal stress on the heart by half, according to a study published online in the journal Circulation. Viagra causes genital blood vessels to expand, which helps in maintaining an erection. Recent research also has pointed to its potential usefulness in treating pulmonary hypertension. Prior to the latest findings by a team of Johns Hopkins researchers, it was thought to have little effect on the heart. Viagra, or sildenafil, blunts the strengthened heart beat caused by chemically induced stress, according to study senior author and cardiologist David Kass, MD, a professor at the Johns Hopkins University School of Medicine and its Heart Institute. It thereby lessens both the excess amount of blood and the force used to pump it to the body. "Sildenafil effectively puts a 'brake' on chemical stimulation of the heart," says Kass. Prevents and Reverses Effects of High BP These findings are believed to be the first confirmation in humans that Viagra has a direct effect on the heart. In earlier research, Kass and his team observed a similar effect in mice; Sildenafil blocked the short-term effects of hormonal stress in the heart. Related studies by the group show that sildenafil also prevents and reverses the long-term effects of chronic high blood pressure on the heart. Sildenafil reversed the negative effects on heart muscle weakened by heart failure and enlargement -- a condition called hypertrophy -- in mouse experiments Kass and his team carried out earlier this year. They reported their results in the journal Nature Medicine. "But we had no firm evidence as to whether or how this therapy might work in the human heart," says Kass. "Our latest research provides firm evidence this drug does indeed have an important impact on the heart." Increased Heartbeat Was Slowed Thirty-five healthy men and women, with an average age of 30 and no previous signs of coronary artery disease, participated in the six-month Johns Hopkins study. Within a three-hour timeframe, each participant received two separate injections of dobutamine (5 micrograms per kilogram for five minutes), a synthetic, adrenaline-like chemical that increases heart rate and pumping strength. Between injections, study participants were assigned randomly to a group that was treated with sildenafil (100 milligrams taken orally) or to a group given a sugar pill placebo. All participants then were given the second dobutamine injection to see what effects sildenafil or placebo had on the heart. Measurements of heart function were made before and after each injection. These included blood pressure readings, electrocardiograms and echocardiograms. Blood samples confirmed relatively equal levels of sildenafil and other enzymes. Each dobutamine injection stimulated heart function, increasing heart rate and the force of each heartbeat used to pump blood throughout the body, results showed. "This stimulation is similar to the way the nervous system normally increases heart function when triggered by emotional or exercise stress, or in diseases such as heart failure," notes Kass. After the first injection of dobutamine, the force of heart contraction increased by 150 percent in both groups. In the placebo group, this increase repeated itself after the second injection. However, in the group treated with sildenafil, the increased heartbeat was slowed by 50 percent, resulting in a smaller increase in blood flow and blood pressure generated by the heart in response to chemical stimulation. Between injections, heart function was not altered in the sildenafil group, demonstrating the absence of adverse side effects on the resting human heart. Stops PDE5A Action "Knowing more about the effects of sildenafil on heart function will allow for safer evaluation of its use as a treatment for heart problems," says Kass. "Our results set the stage for further studies of sildenafil's immediate and long-term effects on the heart and its ability to modify other neurohormonal and stress stimuli, including adrenaline and hypertension," he adds. While the precise biological actions of sildenafil in the heart are not fully understood, the drug is known to work by stopping the action of an enzyme, called phosphodiesterase 5 (PDE5A), Kass explains. This enzyme is involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit overgrowth in the heart. PDE5A is also the biological pathway that sildenafil blocks in the penis to prevent the relaxation of blood vessels and thus maintain erections. Copyright 2005 Daily News Central herbal penis enargement pills vimax review natural penis enlargment and lengthening penis enhancement tool free pennis enlargement technique free penile enlargment pills enlagement erection penis pill vimax penile enlargement surgeon
Since the introduction of Rogaine in the early 1980's, androgenic mediated hair loss, or 'male pattern baldness' has been considered a treatable condition through the use of pharmaceutical preparations. The perception that over-the-counter and prescription drugs are the only means to successfully treat this type of hair loss is perpetuated by the lack of well-funded and publicized studies on the efficacy of natural treatments. However, as the understanding of the biological mechanism of male pattern baldness has become clear through a great body of research, the reality of an effective natural treatment regimen is at hand. After a review of the available natural products, some suggestions will be made for creating your own regimen for treating hair loss naturally. The overall cause of male pattern baldness is now well-known: this type of hair loss seen in about a third of the male population is mediated by the androgenic metabolite of testosterone known as dihydrotestosterone or DHT. The production of this now-infamous hormone increases later in life for many men, along with changes with the receptors for this hormone at the hair follicles. In general, the pertinent hair follicles shrink with continued exposure to the androgenic hormone, some forming only small, villus hairs, while others eventually die completely. Some sources claim these follicles are still getting an adequate blood supply, while others note a waxy buildup or scar-like tissue surrounding the follicles, preventing adequate nutrient delivery. Thus, the localized cause of hair loss, at the follicle level, is still being researched. This does not mean there has been success in discovery of natural hair loss remedies! The regrowth of hair due to androgenic-induced loss should be addressed on two fronts. First, the levels of DHT produced within the body (rather than topically) should be addressed, along with the binding of DHT at it's receptor sites. Second, hair growth should be stimulated topically with application of nutrients and/or DHT suppressors on the follicles themselves. Let's first address the suppression of DHT production and binding systemically (within the body). Prescription drugs such as Finasteride and Dutasteride are available which lower blood levels of DHT, and have been used to improve hair loss conditions. There are now several well-known natural, plant-based products which either reduce testosterone's conversion to DHT (via the 5-alpha-reductase enzyme system), block the binding of DHT to receptor sites, or both. Most common, and most important are Saw Palmetto Berry extract and Stinging Nettle Root extract. These to herbs work in combination to both block the conversion of testosterone to DHT and prevent it's binding to receptor sites in the scalp. Other herbs employed with similar functions include pygeum africanum and pumpkin seed oil, both used to bring into balance the testosterone/DHT ratio; lastly, the plant sterol Beta-Sitosterol is often used successfully to treat prostate enlargement, which has similar causes to male pattern baldness - whether it will support hair growth is not yet known, but it likely won't hurt!. Finally, getting an adequate supply of Zinc is also important in maintaining this hormonal balance. The entire androgen hormone regulation system is fairly complex; just remember these items: Saw Palmetto, Nettle Root (not leaf!), Pygeum, Zinc, and Beta-Sitosterol. By the way, if using a prostate formula for these nutrients, they should be taken in gel cap form - they are better absorbed this way than in plain powder, and hence more effective. In addition to these herbs, which are also commonly used around the world for blocking the creation and effects of DHT, Procyanidins, or Polyphenols, have been shown to inhibit DHT systemically, AND can stimulate hair growth when applied topically. These anti-oxidant compounds first became renown with the discovery of the amazing action of grape seed extract and it's powerful ability as a free-radical scavenger. More recently, Japanese researchers went through the effort of testing HUNDREDS of compounds in the laboratory for their effect on the stimulation of hair growth, and they found the compounds of grape seed extract grew hair at a greater rate than the pharmaceutical preparation Minixodil. With further testing, using variations of the polyphenols, they discovered those found in apple skin polyphenols to be even more effective, nearly twice effective as Rogaine. Further, with the addition of Forskolin, another herbal extract, the effect was even greater. Exciting news! The interesting thing is that these compounds actually stimulated the hair follicles to become active, whereas it seems Rogaine works by lowering blood pressure in the scalp, thereby increasing blood flow to the follicles. And these compounds did not produce an initial 'shedding' as Rogaine has been known to do. Ok, before we get to the good stuff - like how to create your own hair regrowth program, let's look at one more class of natural products - essential oils. Essential oils are powerful, aromatic compounds distilled from plants, with highly regarded medicinal properties, well beyond the effects of only their aromas. Rosemary essential oil has long been considered a 'hair tonic', more than likely because of it's ability to stimulate blood flow locally. A certain type of rosemary, known as rosemary verbenone, also contains compounds which influence skin regeneration. Recall the addition of Retin-A to the use of Rogaine? This was to stimulate the turnover of the skin, increasing the pace of the hair regrowth process. Other essential oils, such as Lavender, have an anti-inflammatory (inflammation is sometimes implicated in hair loss) and skin regenerating effects. Thyme and Cedarwood oils have also been studied, and the combination of these oils has been shown effective at hair growth stimulation in patients with alopecia areata. Given all this wonderful information, how does one combine them into an effective regimen? The best thing to do is keep it simple - the more simple it is, the more likely it is you'll stay with it for the several months it will take to see significant effects. So, for the systemic DHT suppression and inhibition, look at formulas either designed specifically for hair, or those for the support of the Prostate gland - they will contain almost the exact same ingredients. Look for a high-quality supplement, with standardized Saw Palmetto extract, Nettle Root extract, and Pygeum extract. Do not take the un-extracted herbs, they will not likely be strong enough in doses you are willing to consume. Saw Palmetto can be consumed in doses between 160 and 320mg daily, Nettle Root a bit more, and Pygeum significantly less. They should be in a gel cap, preferably in Pumpkin seed oil. Take a separate Beta Sitosterol supplement, around 400mg daily, if it is not included already. This is typically found in dry capsules, and there have not been reports of the importance of consuming this in an oil-based capsule, though you can take it with fatty food if you want to be sure (this may help the absorption). Add an oral supplement of Green Tea extract, Grape Seed extract, or Apple Polyphenol extract if you like, along with a good multivitamin. Now for the topical applications - the polyphenols can be mixed in water. Even better would be to find Nettle Root, grind it up and make a strong tea. To this, create a 1-3% solution by weight of the polyphenols in the liquid and apply twice daily (shake really well or use a blender). Grape seed extract is acceptable, though apple polyphenols would be best. They are hard to come by just yet, but are becoming more popular and available. A bulk supply is best, so you don't have to go opening capsules! A .5-1% addition of Forskolin herb extract can be made io increase effectiveness, but is not completely necessary. Applying right after a shower may make it easier to distribute the liquid on the scalp, and may also increase absorption. It is important to note that increasing the concentration beyond 1% for Grapeseed extract and 3% for Apple polyphenols extract is not advised - higher concentrations did not show increased efficacy - in fact, there may be an opposite effect. For the record, there are about 30 grams of water in one ounce; 1 gram of powder in this is just over a 3% solution. Finally, to this solution, a small amount of the Saw Palmetto blend from a ge lcap can be added - though the efficacy of this has not been noted in the literature. For the essential oils, use 1ml of each oil per one once of carrier oil (a blend of jojoba and grapeseed was used in the study showing hair regrowth in Scottland). Because this is isn't as attractive once applied, though you will smell nice, apply in the evening, before bed, between once a day and once every three days. Or apply during the day some time, massaging into the scalp, and leaving in for 20 minutes to an hour, then wash out. This will give enough time for the oils to penetrate the skin and have their effect. So there it is, the roundup of the more well-known and tested natural remedies for male pattern baldness. While Rogaine for growth stimulation, and Finasteride or Dutasteride for DHT inhibition are completely reasonable ways to go, their costs are high and the effects of their long term use are not well known. And then there are some folks that would prefer to stay away from chemically manufactured medicines altogether - hopefully this bit of information will help. There is much more research available on the internet, though hopefully this is enough information to get you confidently started. penis enlagement system vimax penis pillss in uk manual penile enlargment enlargement erection penis pill vimax home pennis enlargement penis elargement drug penis enlarement doctor herbal penis enlargement pills truth about penile enlargement
AS A RULE, young mother have lots of questions. A baby is so small, he requires constant care and attention, and you’re afraid of hurting him. Genital hygiene causes especially many troubles. As for girls, here we can make for ourselves. But we understand nothing about boys. Let’s learn this science by ourselves. Genital hygiene should be treated very carefully since the very birth. Otherwise, strangury, different inflammations or problems in youth age can occur. In fact, there’s nothing difficult here, you just need to learn several simple rules. Boys During first week, boys can suffer from scrotum edema. Genitals look too big and swelled up. You should not be worried. This is connected with the fact that through placenta or breast milk an excessive quantity of maternal hormones penetrates into a new-born baby’s organism. As a rule, this edema disappears in several days. But if such edema still presents by the end of the second week, apply for a doctor immediately. Intimate hygiene for boys means regular (while each change of a diaper) washing of genitals with warm water. Doing this, you should move a skin wrinkle (foreskin) off a head of a penis necessarily. Fatty substance (smegma) is accumulated there, which should be removed. If you see reddening on foreskin, then you need to cleanse it with a cotton tampon, moistened in a light (light-pink) manganese solution or bur-marigold extract several times a day. Sometimes, foreskin can be very narrow and does not allow baring a head of penis completely. In such case, it’s desirable to apply for a doctor as soon as possible. As a rule, a surgeon just needs to make a small cut of a skin wrinkle. And the earlier he does such operation, the better. If a baby has very sensitive skin, then you may sometimes do just “dry” washing with the help of wet or oiled tissues. You should wash a baby’s genitals with soap no less than once in 4-5 days. Girls In the end of the first week of a girl’s life you may notice mucous excreta or excreta with some blood. As a rule, they disappear by itself in 2-3 days. This is also connected with excessive amount of maternal hormones coming to a girls’ organism. During this period, a baby needs careful care. Diapers should be changed every 1,5-2 hours. If excreta still take place for more than 3 days, you need to apply for a doctor. Girls’ genitals are very sensitive and have rather low resistibility to different infections. The most common “female” disease of new-born babies is vulvitis (inflammation of external genitals). So, keep them clean and warm all the time. Every time you change a diaper, wash your daughter with warm water. You can wash her either under tap or with a cotton tampon moistened in water. Move from pubis to coccyx, to prevent excesses of excrement from coming to genitals. Soap should also be used no more than once in 4-5 days, to prevent skin from getting too dry. And yet, try not to take a great interest in babies’ cosmetics. Use various creams, oils and powders only in case of need (while irritations and diaper rashes), not regularly. Otherwise you will break a natural protective skin layer of a new-born. penis elargement photo free penis enlargment pills enlargement free penis pill sample penis enlargement secret penis enargement information penile enlargement technique pennis enlargement product penis elargement stretcher truth about penile enlargement
Penis girth is the measure of how thick around your penis is. This is sometimes overlooked but is very important, especially to women. It just so happens that the first 1/3 of a woman’s vagina feels the most sensation. Now you see why it’s important to stimulate this area. But while most guys are worried about their size in terms of length, it is the girth that really makes their partner happy. But before I continue, let me clear up a common myth: any average vagina can be stretched to fit the largest of penises (world record is around 13 inches long!). Entire babies can fit through there, and so can any male member. Preparing her for entry is the most important step for success. What is the average size in girth? A survey from the Durex condom company says the average girth is 5.2 inches. This study was done on almost 3,000 men from 27 countries. How to measure your penis girth My favorite penis exercise site, Penis-Health, offers the following advice when measuring girth. First make sure your penis is 100% erect and hold it out so it’s parallel to the floor. Wrap a tape measure around the thickest part of your penis, but don’t pull too tight. What you can do to improve your penis girth size A small penis size can have a huge effect on a guy’s outlook on life. This is because many men think their penis size says what type of man they are. A man with a less than average sized penis can practice natural penis enlargement exercises to increase his size in girth, and length. This is what worked for me the best, and over 80% of men doing natural penis enlargement do exercises. Natural enlargement exercises push blood to new areas of the penis. There are a lot of tiny blood vessels that have poor circulation, and they will get used now. You will start to fill these areas with blood during erections, expanding your girth and length. Exercises will also stretch and grow new tissue, adding one to three full inches in size. Penis girth is important and can improve sex for both partners. A good way to improve girth and overall penile fitness is to try natural enlargement exercises. These special exercises fill the penis with more blood for larger, harder erections. erection penis pill size vimax penis enlargement pill magna rx penis enlagement program top penis enargement pills best enlargement exercise pennis penis enlarement doctor compare penile enlargment pills pro solution review truth about penile enlargement
Bad breath affects children in the same way it affects adults. It is not necessarily a sign of a more serious health condition though, but a frequent bad breath in children can be distressing not only for the child, but for the parents too. There are a number of causes associated with frequent bad breath in children. Some medical researches have noted that a frequent bad breath in children may be caused normally by mouth breathing due to colds, allergies, sinus infections, or enlargement of tonsils blocking the nasal passages; dehydration; thumb sucking; increased bacterial activity in the mouth at night; infrequent snacking and drinking throughout the day; and improper brushing. All of these are deemed culprits for the reason that they tend to cause mouth drying, which in turn allows the increase of the number of bacteria in the mouth resulting to a stinky breath. Knowing the culprits, it is now so far understandable that the real root of frequent bad breath in children is mouth drying. So to prevent or cure frequent bad breath in children, it is necessary to maintain the saliva production so to decrease the mouth bacteria. But, the question is in what possible way will the saliva production be increased? Well, there are actually a lot of ways that parents may consider to treat their child’s bad breath. One of the best ways is to ensure that your child gets plenty of fluids throughout the day. This is pretty self-explanatory as less fluids means less saliva, and less saliva means a dryer mouth. So if possible, offer frequent drinks throughout the day as it may helps flush out the odor-causing bacteria in your child’s mouth. In case of allergy and colds, a frequent bad breath in children can be prevented by treating the problem with saline or a nasal aspirator suctioned in your child’s nose. You can apply this to your child at night before he or she goes to bed. In this way, post-nasal drip as well as mouth breathing can be reduced. Post-nasal drip and mouth breathing as mentioned earlier are two common causes of frequent bad breath in children. To further treat frequent bad breath in children, try to teach your children the importance of oral hygiene. Make your child aware that proper cleaning of the mouth right after every meal is very important in treating frequent bad breath he or she is suffering from. Also, teach your child the proper way of brushing the teeth. Assist your child, but while you are helping, make sure that your child knows the importance of brushing not only the teeth, but also the tongue and sides of the mouth. Also teach your child the proper way of flossing. If after doing all of these suggestions mentioned above and you still find your child suffering from frequent bad breath, don’t hesitate to call or see a doctor. A frequent bad breath in children that appears after four to five days of the initial treatment may signal something serious. It could mean an infection, or something that is chronic. So call your dentist or your child’s physician and talk about the problem.